| Result | Offense | Defense | Week | Date | Opponent | W/L | Score | Total (yd) | Pass (yd) | Rush (yd) | 1st Downs | TO's | Total (yd) | Pass (yd) | Rush (yd) | 1st Downs | TO's |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 09/07/2006 | Miami Dolphins | W | 28 - 17 | 342 | 196 | 146 | 20 | 1 | 278 | 240 | 38 | 15 | 2 |
| 2 | 09/18/2006 | @ Jacksonville Jaguars | L | 0 - 9 | 153 | 127 | 26 | 9 | 2 | 362 | 252 | 110 | 17 | 1 |
| 3 | 09/24/2006 | Cincinnati Bengals | L | 20 - 28 | 365 | 195 | 170 | 27 | 5 | 246 | 159 | 87 | 15 | 3 |
| 4 | 10/01/2006 | Bye Week | ||||||||||||
| 5 | 10/08/2006 | @ San Diego Chargers | L | 13 - 23 | 265 | 197 | 68 | 16 | 2 | 341 | 222 | 119 | 22 | 1 |
| 6 | 10/15/2006 | Kansas City Chiefs | W | 45 - 7 | 457 | 238 | 219 | 23 | 1 | 213 | 175 | 38 | 14 | 3 |
| 7 | 10/22/2006 | @ Atlanta Falcons | L | 38 - 41 | 473 | 418 | 55 | 27 | 3 | 399 | 226 | 173 | 24 | 2 |
| 8 | 10/29/2006 | @ Las Vegas Raiders | L | 13 - 20 | 360 | 271 | 89 | 15 | 4 | 98 | 17 | 81 | 9 | 1 |
| 9 | 11/05/2006 | Denver Broncos | L | 20 - 31 | 499 | 403 | 96 | 27 | 6 | 336 | 221 | 115 | 13 | 0 |
| 10 | 11/12/2006 | New Orleans Saints | W | 38 - 31 | 467 | 250 | 217 | 19 | 0 | 513 | 393 | 120 | 29 | 3 |
| 11 | 11/19/2006 | @ Cleveland Browns | W | 24 - 20 | 338 | 261 | 77 | 23 | 3 | 302 | 203 | 99 | 15 | 2 |
| 12 | 11/26/2006 | @ Baltimore Ravens | L | 0 - 27 | 172 | 151 | 21 | 17 | 3 | 275 | 161 | 114 | 19 | 0 |
| 13 | 12/03/2006 | Tampa Bay Buccaneers | W | 20 - 3 | 267 | 191 | 76 | 13 | 1 | 254 | 144 | 110 | 16 | 4 |
| 14 | 12/07/2006 | Cleveland Browns | W | 27 - 7 | 528 | 225 | 303 | 26 | 1 | 294 | 276 | 18 | 11 | 2 |
| 15 | 12/17/2006 | @ Carolina Panthers | W | 37 - 3 | 306 | 147 | 159 | 20 | 0 | 240 | 197 | 43 | 12 | 2 |
| 16 | 12/24/2006 | Baltimore Ravens | L | 7 - 31 | 251 | 188 | 63 | 16 | 3 | 359 | 256 | 103 | 23 | 3 |
| 17 | 12/31/2006 | @ Cincinnati Bengals | W | 23 - 17 | 482 | 275 | 207 | 29 | 2 | 295 | 251 | 44 | 15 | 0 |